cutaneous kikuchi disease

Di Lernia V, Bajocchi G, Piana S. Subacute cutaneous lupus erythematosus onset preceded by Kikuchi-Fujimoto disease. Loretta S Davis, MD is a member of the following medical societies: American Academy of DermatologyDisclosure: Nothing to disclose. Kikuchi-Fujimoto Disease: A Review. After desk review, manuscripts related to COVID-19 chosen for peer review will undergo rapid review. Sangre (Barc). [Medline]. Upon acceptance, the accepted manuscript will be posted on the journal website. to maintaining your privacy and will not share your personal information without A wide variety of morphologies exist, and biopsy is required for diagnosis. Subacute necrotizing lymphadenitis-a collective clinicopathological and immunohistochemical study. It has been report-ed that up to 40% of patients with Kikuchi´s disease have also cutaneous eruptions, but no specific skin changes ; Thompson, Curtis T. Each patient had a lymph node biopsy showing the typical necrotizing lymphadenitis of KD. the following in cutaneous Kikuchi disease patients: (i) slight predominance of CD8+ lymphocytes, (ii) lymphohistiocytic infiltration and nonneutrophilic karyorrhexis (usually). Noah S Scheinfeld, JD, MD, FAAD is a member of the following medical societies: American Academy of DermatologyDisclosure: Nothing to disclose. Cutaneous Rosai-Dorfman Disease: A Clinical and Histopathologic Study of 25 Cases in China, Spectrum of Clinicopathologic Findings in COVID-19-induced Skin Lesions: Demonstration of Direct Viral Infection of the Endothelial Cells, The Morphologic Spectrum of T-Cell Lymphoma, Atypical and Malignant Neoplasms Showing Lipomatous Differentiation: A Study of 111 Cases, Neuromas of the Appendix: A Light-Microscopic, Immunohistochemical and Electron-Microscopic Study of 20 Cases. Sopeña B, Rivera A, Vázquez-triñanes C, et al. Ann Dermatol Venereol. It is a rare disorder with incidence ranging from 0.54% to 1.5% in Saudi Arabia and 5.7 % in Taiwan.1,2 Epidemiology The incidence of Kikuchi Fujimoto Disease (KDF), also called histiocytic necrotizing lymphadenitis is 2012;41(6):900-6. This book will help cytopathologists to conduct these tasks in various organs and clinical contexts. Clin Med Insights Ear Nose Throat. 10 Courtesy of Nephron (own work), via Wikimedia Commons. [Medline]. The incidence and clinical characteristics by gender differences in patients with Kikuchi-Fujimoto disease. It normally manifests as persistent, isolated cervical adenopathy with a … As the nomenclature and description of the disease spectrum under the descriptive term parapsoriasis evolved, the primary focus has been on the distinction of whether the disorder progresses to mycosis fungoides (MF) or cutaneous T-cell lymphoma (CTCL). Very high magnification micrograph of histiocytic necrotizing lymphadenitis, also known as Kikuchi disease. CD30 expression: a diagnostic pitfall for primary cutaneous gamma delta T cell lymphoma Source: Annals of Hematology - September 15, 2021 Category: Hematology Source Type: research Quantitative evaluation of interim positron emission tomography in peripheral T-cell lymphoma 9. Kikuchi's disease is a benign, self-limiting disease, whose pathogenesis remains unknown. CD30+ cutaneous T-cell lymphoma. 59 (1):130-6. 1992; 33:32–40. Bookshelf Cutaneous involvement by Kikuchi's disease may also denote a worse clinical course. Kikuchi Disease A disease commonly caused by fever and a crucial stage of lymphadenopathy is known as Kikuchi-Fujimoto and the other name for this disease is Kikuchi’s necrotizing of histolytic.. We report a case of Kikuchi-Fujimoto disease with skin and lymph node involvement. Abstract: Kikuchi–Fujimoto disease, or histiocytic necrotizing lymphadenitis, is an infrequent idiopathic disorder. reported cutaneous manifestation in 40% of patients with kikuchi’s disease; they may be manifested either simultaneously or after the illness. The histopathology of cutaneous lesions of Kikuchi's disease (necrotizing lymphadenitis): A report of five cases. All registration fields are required. Semin Arthritis Rheum. Found inside – Page 1520Cutaneous Kikuchi's disease. Am J Surg Pathol. 1991;15:1012–1014. Sumiyoshi Y, Kikuchi M, Takeshita M, et al. Immunohistochemical study of skin involvement ... At the same time, experienced dermatologists will find this book a valuable reference work for differential diagnosis. Conceived as a guide for practitioners in their work in dermatology, this book is unique in its approach. The Merck Manual was first published in 1899 as a … 800-638-3030 (within USA), 301-223-2300 (international). Hematoxylin and eosin stain. Letawe C, Piérard-Franchimont C, Rustom KA, Hermanns-Lê T, Piérard GE. Unable to load your collection due to an error, Unable to load your delegates due to an error. Awareness of this disorder helps prevent misdiagnosis and inappropriate treatment. Email-robedamin@yahoo.com Bangladesh J Medicine 2013; 24 : 70-77 fBJM Vol. Arch Dermatol. 2007 Dec. 29 (12):864. These aforementioned features have been described in cutaneous lesions of Kikuchi-Fujimoto disease, an entity whose clinicopathologic findings overlap with both infectious mononucleosis and lupus erythematosus. Cutaneous lymphoma. Kikuchi-Fujimoto disease and systemic lupus erythematosus. Learn more > COVID-19: Continuing the Conversation. Kikuchi's disease occurs world wide and has been often confused with toxoplasmosis, cat scratch disease, tuberculosis, infectious mononucleosis, and non-Hodgkin's lymphoma. Lupus is an autoimmune disease that can affect almost every organ in the body. The etiology of KFD remains uncertain, but associations … [1, 2] KD is most common in Asians and typically affects females younger than 40 years. Sopeña B, Rivera A, Vázquez-Triñanes C, Fluiters E, González-Carreró J, del Pozo M, et al. However, KD can evolve into lupus erythematosus, in which case morbidity and mortality are substantially increased. Found inside – Page 786Kikuchi's disease: case report and systematic review of cutaneous and histopathologic presentations. J Am Acad Dermatol 2008;59:130–6. [3] One study by Dumas et al examined 91 patients with KD. Naika. 51 (1):34-36. ต่อมน้ำเหลืองโตไม่ทราบเหตุ วินิจฉัยจากผลชิ้นเนื้อ. Registered users can save articles, searches, and manage email alerts. Lymphadenitis is the inflammation or enlargement of a lymph node. Spies, Jessica M.D. Cutaneous B-cell lymphoma. J Am Acad Dermatol. 24 (6):551-4. Kikuchi-Fujimoto disease (KFD), also known as histiocytic necrotizing lymphadenitis, is a relatively rare condition characterized by subacute necrotizing regional lymphadenopathy. Hydroxychloroquine (Plaquenil®) is a 4-amino-quinoline antimalarial medication that is widely used to treat systemic lupus erythematosus (SLE), rheumatoid arthritis, and related inflammatory and dermatological conditions. Diseases & Conditions, 2002 2000 Aug. 22 (4):328-33. This book is an excellent starting point for the analysis of drug-induced findings in toxicity studies. ; LeBoit, Philip E. M.D. Imai K, Yokozeki H, Nishioka K. Kikuchi's disease (histiocytic necrotizing lymphadenitis) with cutaneous involvement. The histopathology of cutaneous lesions of Kikuchi's disease (necrotizing lymphadenitis): a report of five cases. Kim KJ, Jee MS, Chang SE, Choi JH, Sung KJ, Moon KC, et al. Observation Diseases & Conditions, encoded search term (Cutaneous Kikuchi Disease) and Cutaneous Kikuchi Disease, Dermatologic Manifestations of Mycobacterium Avium-Intracellulare Infection, Enigmatic Kikuchi-Fujimoto Disease: A Comprehensive Review, Fast Five Quiz: Plaque Psoriasis Presentation and Diagnosis, Fast Five Quiz: Plaque Psoriasis Management. Kikuchi-Fujimoto disease is a rare, self-limited benign necrotizing lymphadenitis that typically manifests as fever and lymphadenopathy with or without extension to other organs including the skin, eyes, and bone marrow. Chung said dermatologists can treat these patients with more supportive measures, including analgesics, antipyretics, and rest. Skin biopsies from all five patients shared a specific constellation of histologic features: vacuolar interface change with necrotic keratinocytes, a dense lymphohistiocytic superficial and deep perivascular and interstitial infiltrate, varying amounts of papillary dermal edema, and abundant karyorrhectic debris with a conspicuous absence of neutrophils and a paucity of plasma cells, paralleling the nodal histology in KD. Kikuchi-Fujimoto disease (KFD) is a self-limited histiocytic necrotizing lymphadenitis sometimes affecting the skin. Lymph node histopathology of KD is diagnostic, revealing characteristic necrosis, histiocytic infiltration, and karyorrhectic debris without neutrophils. Kikuchi's disease (KD) is a benign self-limiting febrile illness usually affecting young women, which is manifested clinically by fever and cervical lymphadenopathy. Cutaneous T cell lymphoma. Investigators have postulated that apoptosis plays an important part in the pathogenesis of KD, as apoptosis leading to necrosis is a prominent finding in both lymph nodes and skin affected by KD. Abstract Background Interstitial lung disease (ILD) is a common manifestation of systemic sclerosis and a leading cause of systemic sclerosis–related death. What is hydroxychloroquine? Pediatr Infect Dis J. The relationship between Kikuchi–Fujimoto disease and lupus erythematous remains a matter of debate. [Medline]. For immediate assistance, contact Customer Service: Patients with Kikuchi-Fujimoto disease require long-term monitoring for the development of SLE, which has been reported to occurinupto25%ofcases.Kikuchi-Fujimotodisease may precede, postdate, or coincide with SLE diag-nosis.6 Patients with positive serologies who experi-ence arthralgias, skin manifestations, and weight loss Perry AM, Choi SM. We report a case of Kikuchi-Fujimoto disease with skin and lymph node involvement. Sir : Kikuchi's disease (KD) is a self‐limiting histiocytic necrotizing lymphadenitis (HNL) rarely associated with cutaneous lesions; it is considered to be related to lupus erythematosus (LE) because it may evolve into systemic or cutaneous LE. Address correspondence and reprint requests to Dr. Curtis Thompson, Division of Dermatopathology, Department of Pathology, University of New Mexico Health Sciences Center, 2211 Lomas Boulevard, NE, Albuquerque, NM 87106, U.S.A. Kikuchi's disease (KD) is an idiopathic, self-limited necrotizing lymphadenitis that can clinically and histologically mimic high-grade lymphoma, including Hodgkin's disease, or can be mistaken for the lymphadenitis of systemic lupus erythematosus (SLE). Kikuchi’s disease: case report and systematic review of cutaneous and histopathologic presentations. Semin Diagn Pathol. Kikuchi-Fujimoto's necrotizing lymphadenitis in association with discoid lupus erthematosus: a case report. 2003 Mar. Learn more > 2012 Sep 15. [Recurrent Kikuchi's disease in a patient with discoid lupus]. doi: 10.1097/RHU.0000000000001279. Found inside – Page 1This book is a comprehensive overview of the fungi that are clinically relevant for animals and humans. This book provides an in depth overview of Neutrophilic Dermatoses, a group of diseases that includes Sweet’s syndrome, pyoderma gangrenosum and subcorneal pustular dermatosis. of Kikuchi-Fujimoto disease. 4. Arch Pathol Lab Med. bone marrow and skin involvement. [17] Furthermore, studies have demonstrated an increased risk of disease in patients with certain HLA haplotypes, specifically HLA-DPA1 and HLA-DPB1. [Medline]. Medicine (Baltimore). Kikuchi's disease occurs world wide and has been often confused with toxoplasmosis, cat scratch disease, tuberculosis, infectious mononucleosis, and non-Hodgkin's lymphoma. [Medline]. Kikuchi disease was described in 1972 in Japan. DeFilipp Z. Cutaneous manifestation of Kikuchi-Fujimoto disease in the setting of granulomatosis with polyangiitis (Wegener's). a rare disease that is frequently underdiagnosed due to clinical features that are similar to those of non-Hodgkin lymphomas, systemic lupus erythematosus (SLE), or infectious reactive lymphadenopathy. 1999 Nov. 126 (11):826-8. Dirk M Elston, MD Professor and Chairman, Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina College of Medicine Certain skin features, such as the erythematous facial lesions, hemorrhagic crusting on lips, and oral ulcers, as evidenced in our patient, should be considered possible cutaneous manifestations of Kikuchi.Fujimoto disease. 2018 Jan - Mar. PLoS One. Found insideAnnotation copyrighted by Book News, Inc., Portland, OR ), Department of Pathology and Dermatology, University of California, San Francisco, San Francisco, California, U.S.A. Basics topic Hypercoagulable state – Coronavirus disease 2019… COVID-19: Outpatient evaluation and management of acute illness in adults …(You can also locate patient education articles on a variety of subjects by searching on "patient info " and the keyword(s) of interest.) The most frequent clinical manifestations include lymphadenopathy, fever, cutaneous lesions, arthritis, fatigue, and hepatosplenomegaly. The Cutaneous manifestation associated with kikuchi’s disease is relatively common. Pathol. ; Foucar, Kathy M.D. This disease is usually accompanied by night sweats, rashes, and headaches. Am J Surg Pathol. [9], Females are more commonly affected than males, with a female-to-male ratio of 4:1. Kikuchi disease with facial rash and erythema multiforme. George TI, Jones CD, Zehnder JL, Warnke RA, Dorfman RF. 2004 Nov-Dec. 8 (6):442-5. [Medline]. Eboriadou M, Tragiannidis A, Markou K, Athanassiadou F. Kikuchi-fujimoto disease associated with extreme leukopenia and thrombocytopenia in an adolescent boy. There was only rare staining with TIA-1 and CD30. Antinuclear antibodies , antiphospholipid antibodies , anti-dsDNA , and rheumatoid factor are usually negative, and may help in differentiation from systemic lupus erythematosus . [3, 4, 5, 6] The presence of lymphadenopathy with systemic symptoms often raises concern for lymphoma, prompting lymph node biopsy. modify the keyword list to augment your search. [Medline]. Found insideWritten and edited by leading international experts in the field, this is an essential resource for trainee pediatric pathologists, as well as general pathologists who may encounter pediatric cases. Egashira K, Origuchi H, Sagara T, Kikuchi Y "Coronary artery spasm during hydrocortisone-induced allergic reactions." Epidemiology and Characteristics of Kikuchi-Fujimoto Disease in the African-Descent Population of Martinique, French West Indies. Conclusions: Persistent posterior triangle lymphadenopathy in the 16-40 year old age group warrants “Red Flag” referral to rule out serious pathology such as HIV, metastatic cancer or lymphoma. [Medline]. It has been report-ed that up to 40% of patients with Kikuchi´s disease have also cutaneous eruptions, but no specific skin changes Atwater AR, Longley BJ, Aughenbaugh WD. Clin Exp Dermatol. [Medline]. The clinical impression was variable according to the various cutaneous manifestations. 210752-overview KD is a self-limited condition; however, patients with KD, and especially cutaneous KD, have an increased risk of cutaneous and/or systemic lupus erythematosus and thus should have appropriate long-term follow up and monitoring. Although the clinical and histopathologic findings are very heterogenous, the presence of a lymphohistiocytic infiltration with nonneutrophilic karyorrhexis helps to make the diagnosis of Kikuchi's disease with skin involvement. 5. The skin biopsies showed vacuolar interface changes (12/16; 75.0%), necrotic keratinocytes (11/16; 68.8%), superficial (16/16; 100.0%) and deep (9/16; 56.3%) lymphohistiocytic infiltration, karyorrhexis (16/16; 100.0%), deposition of mucin (5/16; 31.3%), and panniculitis (9/15; 60.0%). Kikuchi-Fujimoto disease (KFD) is a rare and benign disorder that usually occurs in young adults with enlarged lymph nodes containing infiltrate of cytotoxic T cells and nuclear debris. Loretta S Davis, MD Professor and Chair, Department of Dermatology, Medical College of Georgia, Augusta University Cutaneous T-cell lymphoma (CTCL) is characterized by a primary sporadic T-cell proliferation in the skin. Menasce LP, Banerjee SS, Edmondson D, Harris M. Histiocytic necrotizing lymphadenitis (Kikuchi-Fujimoto disease): Continuing diagnostic difficulties. Noah S Scheinfeld, JD, MD, FAAD † Assistant Clinical Professor, Department of Dermatology, Weil Cornell Medical College; Consulting Staff, Department of Dermatology, St Luke's Roosevelt Hospital Center, Beth Israel Medical Center, New York Eye and Ear Infirmary; Assistant Attending Dermatologist, New York Presbyterian Hospital; Assistant Attending Dermatologist, Lenox Hill Hospital, North Shore-LIJ Health System; Private Practice https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cDovL2VtZWRpY2luZS5tZWRzY2FwZS5jb20vYXJ0aWNsZS8xMTI0OTU3LW92ZXJ2aWV3. Lupus. Kikuchi-Fujimoto disease: a diagnostic dilemma. Found inside – Page 102skin. Kikuchi's disease involving lymph node and skin - 103 *. P. E. LEBOIT Age:33 years Sex: F Clinical features: After two months of supraclavicular ... Kikuchi–Fujimoto disease (KFD), also known as Kikuchi disease, is a rare lymphohistiocytic disor-der first described in 1972.1,2 KFD generally affects women of Asian descent between the ages of 20 and 35 years and has a male:female ratio of 1:2; howev-er, new cases of KFD have also been described in Despite many studies in the literature, the cause of KFD remains uncertain. The book provides an authoritative source of knowledge about these problematic disorders. It bridges the gap between clinical recognition and the new molecular medicine. The subacute necrotizing histiocytic lymphadenitis was reported for the first time in 1972 in Japan by Kikuchi and by Fujimoto and his colleagues. [Cutaneous-lymph node Kikuchi-Fujimoto disease]. Although it has been reported that some patients with Kikuchi's disease have cutaneous manifestations, the specific skin changes of patients with Kikuchi's disease have not been fully described. Found inside – Page iThis volume provides a comprehensive and world-class review of the field of histiocytic neoplasms and hemophagocytic lymphohistiocytosis (HLH). 2014 Jan. 4 (1):47-9. We report a 38-year-old male patient who presented with cutaneous lesions mimicking widespread discoid lupus erythematosus with high-grade fever, arthralgia and lymphadenopathy. [Medline]. Ann Dermatol Venereol. J Am Acad Dermatol 1994;30:504-6. 12:1179550619828680. This book addresses a wide range of topics relating to head and neck and endocrine surgery, including: maxillofacial injuries, surgery of the scalp, surgery of the salivary glands, jaw tumors, surgery of the oral cavity (lips, tongue, floor ... 41 (6):900-6. Many conditions affect the human integumentary system—the organ system covering the entire surface of the body and composed of skin, hair, nails, and related muscle and glands. The current study presents one case of combining Kikuchi’s lymphadenitis in inguinal lymph nodes and primary cutaneous squamous Patients who have cutaneous KD may have an increased risk of developing systemic lupus erythematosus and thus should be closely monitored. [Medline]. 10 J Coll Physicians Surg Pak. For information on cookies and how you can disable them visit our Privacy and Cookie Policy. 5. The cutaneous lesions of Kikuchi's disease: a comprehensive analysis of 16 cases based on the clinicopathologic, immunohistochemical, and immunofluorescence studies with an emphasis on the differential diagnosis. Given that there have been considerable advances in the treatment and management of oncologic diseases in children, the fifth edition of this successful clinical manual will be entirely updated to incorporate all current protocols and ... Kikuchi disease, also known as histiocytic necrotizing lymphadenitis or Kikuchi-Fujimoto disease, is a rare condition that typically presents with fever and cervical lymphadenopathy in previously healthy young women. Kikuchi disease with cutaneous involvement complicated by features of hemophagocytic lymphohistiocytosis Alison M. Treichel, Noelle Teske , Travis Vandergriff, Arturo Dominguez, Melissa M. Mauskar, Khang D. Nguyen 2002 10 Previous studies have shown that the simultaneous existence of Kikuchi’s lymphadenitis and carcinoma is extremely rare [3-10]. Kikuchi disease (KD), also termed Kikuchi-Fujimoto disease or benign histiocytic necrotizing lymphadenitis, is a rare disorder most common in Asian females that presents with systemic symptoms and cervical lymphadenopathy. CD30+ cutaneous T-cell lymphoma. Patients most often present with cervical lymphadenopathy, sometimes associated with fever and leukopenia. Clipboard, Search History, and several other advanced features are temporarily unavailable. The histopathology of cutaneous lesions of Kikuchi's disease (necrotizing lymphadenitis): a report of five cases. It generally affects young individuals, especially females, of Oriental-Asian origin. [Medline]. MedTerms medical dictionary is the medical terminology for MedicineNet.com. Serologic evidence of active and chronic active EBV infection was found in … Although cervical lymphadenitis in young women is the most familiar clinical presentation, it may take place in the etiology of fever in cases presenting with fever of unknown origin. Kikuchi – Fujimoto Disease (KFD) is a benign, self-limited, inflammatory disorder, first reported in Japan. Direct immunofluorescence staining and EBER in situ hybridization were all negative. … Virchows Arch. Arthritis Care Res (Hoboken). 2003 Mar;13(3):138-42. This book presents, for the first time, a comprehensive overview on the strikingly manifold patterns and peculiarities of mosaic skin disorders. [Medline]. DeFilipp Z. 1999 Sep. 23(9):1040-7. . NCI CPTC Antibody Characterization Program. Your account has been temporarily locked due to incorrect sign in attempts and will be automatically unlocked in The Journal of Pediatrics encourages submissions relating to the scientific and health policy implications of the current COVID-19 pandemic that are specific to infants, children, and adolescents. We describe one such case of KD in a 33-year-old Bulgarian woman who presented with cervical and axillary … Am J Surg Pathol 1994;18:219, Hum Pathol 1993;24:1114, J Clin Pathol 1985;38:1252, eMedicine: Kikuchi Disease [Accessed 29 June 2018], eMedicine: Cutaneous Kikuchi Disease [Accessed 29 … The histologic examination revealed a necrotizing lymphadenitis with blast cells but devoid of neutrophils. It is also known as histiocytic necrotizing lymphadenitis, Kikuchi necrotizing lymphadenitis, phagocytic necrotizing lymphadenitis, subacute necrotizing lymphadenitis, and necrotizing lymphadenitis. Kikuchi disease occurs sporadically in people with no family history of the condition. Honda F, Tsuboi H, Toko H, Ohyama A, Takahashi H, Abe S, et al. Keywords Jung IY, Ann HW, Kim JJ, Lee SJ, Kim J, Seong H, et al. Please confirm that you would like to log out of Medscape. [3]. All the patients had histiocytic necrotizing lymphadenitis. 1972. 3. Patients should know that Kikuchi disease (KD) is a benign and self-limited condition. Search for Similar Articles About 16.6% to 40% of patients with KD are reported to have cutaneous involvement. Most studies site recurrence rates of around 3-4%, 35:379-380. J Am Acad Dermatol. [3], This disease affects Asians more than other races, but it has been reported worldwide. Articles in PubMed by Jessica Spies, M.D. Rao GS, Vohra D, Kuruvilla M. Is Kikuchi-Fujimoto disease a manifestation of systemic lupus erythematosus?. This idiopathic disease can affect the skin. 1124957-overview 2006 Apr. Kikuchi's disease: case report and systematic review of cutaneous and histopathologic presentations. Please try again soon. Immunohistochemistry, immunofluorescence, and Epstein-Barr virus-encoded RNA (EBER) in situ hybridization were performed. Viral Immunol. J Korean Med Sci. 2017 Dec 15. 2010 Dec. 169 (12):1557-9. 18 (9):8. Lauerma AI, Reitamo S, Maibach HI "Systemic hydrocortisone/cortisol induces allergic skin reactions in presensitized subjects." This may precede, coincide with or develop after the presentation of Kikuchi's disease [5, 6]. Am J Surg Pathol. Kikuchi′s disease (KD), also known as Kikuchi-Fujimoto disease and histiocytic necrotizing lymphadenitis, is a rare, self-limiting condition, characteristically involving the lymph nodes. Found insideIn addition to being a clinical primer, this is also a work of scientific research and contains the first printed description of two new syndromes. KuoTT, SKLo. 1. Rev Esp Patol. Cutaneous manifestation of Kikuchi's histiocytic necrotizing lymphadenitis. Found insideThis book is a printed edition of the Special Issue "Plant Extracts in Skin Care Products" that was published in Cosmetics 2020 Mar 18;12(3):e7312. Autoimmune manifestations of Kikuchi disease. an enigmatic benign and self-limited acute or subacute syndrome of unknown etiology that presents with localized lymphadenopathy and fever, evolving during a period of 3-6 weeks. Thai LH, Ingen-Housz-Oro S, Godeau B, Rethers L, Wolkenstein P, Limal N, Papillon V, Kapfer J, Chosidow O, Ortonne N. Medicine (Baltimore). Additional lymph node and skin biopsies, however, revealed karyorrhectic debris without neutrophils and numerous CD68‐positive cells, a characteristic finding of Kikuchi's disease (KD). หรือ เรียกว่า histiocytic necrotizing lymphadenitis หรือ Kikuchi-Fujimoto disease. [8, 9, 10, 11, 12] Fortunately, KD is usually self-limited, resolving on its own in 1-4 months. Skin involvement in KD is very rare and is evident clinically in the form of skin rashes and nodules.
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